Interleukin-1β impairs brain derived neurotrophic factor-induced signal transduction
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چکیده
منابع مشابه
Involvement of Mice Hippocampus Brain-derived Neurotrophic Factor in Diazinon-induced Depressive Behavior in Mice
Background: Diazinon (Dzn), an Organophosphorus (OP) pesticide, is extensively used in agriculture. Acetylcholinesterase inhibition is linked to OP toxicity, and there are major mental health concerns associated with the use of pesticides. The objective of this study was to assess the depressive behavior in an animal model following their exposure to Dzn and the effect on the Brain-Derived Neur...
متن کاملBrain-derived neurotrophic factor:
Dekan Summary BDNF (brain-derived neurotrophic factor) plays an important role in neuronal survival, growth and maintenance of several neuronal systems, serves as neurotransmitter modulator and participates in plasticity important for learning and memory. BDNF is widely expressed in the CNS, beginning early in development and extending throughout life. In the mammalian brain, it is most abundan...
متن کاملGlial cell-derived neurotrophic factor (GDNF)-induced migration and signal transduction in corneal epithelial cells.
PURPOSE To identify signal-transduction pathways induced by glial cell-derived neurotrophic factor (GDNF) in corneal epithelial cells and to characterize its effect on cell migration. METHODS Expression of GDNF receptor (GFR) alpha-1 in human corneal epithelium was detected by RT-PCR and Western blot analysis. Expression and phosphorylation of Ret, activation of focal adhesion kinase (FAK) an...
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We evaluated the ability of brain-derived neurotrophic factor (BDNF) to decrease the chemosensitivity of neuroblastoma cells to cisplatin. Two cell lines, one derived from SH-SY5Y (SY5Y-TB8) and the other from SK-N-AS (AS-TB8), transfected with a TrkB plasmid were generated, and used to assess the effects of activation of the TrkB signal transduction path on cisplatin (Cis) induced apoptosis. B...
متن کاملChanges of Interleukin-6 and brain-derived neurotrophic factor levels following acute plyometric training among inactive men
ABSTRACT Introduction: Brain-Derived Neurotrophic Factor (BDNF) plays an important role in transmission of nerve impulses, plasticity, growth, and generally in the health of nervous system. Interleukin-6 (IL-6) is involved in immune and inflammatory responses and is produced by immune cells, fibroblasts, endothelial cells, skeletal muscles, and fat tissues. The aim of this study ...
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ژورنال
عنوان ژورنال: Neurobiology of Aging
سال: 2008
ISSN: 0197-4580
DOI: 10.1016/j.neurobiolaging.2007.02.027